One fated sadly to be unappreciative of music (4-4)
I believe the answer is:
tone-deaf
'to be unappreciative of music' is the definition.
I can't tell whether this definition defines the answer.
'one fated sadly' is the wordplay.
'sadly' is an anagram indicator.
'one'+'fated'='onefated'
'onefated' anagrammed gives 'TONE-DEAF'.
Can you help me to learn more?
(Other definitions for tone-deaf that I've seen before include "Musically challenged" , "Unable to distinguish differences in musical pitch" , "Unable to distinguish variations in musical pitch" , "Unable to discriminate between musical notes" , "Unable to perceive musical pitch accurately" .)