One from Latvia interrupting Uruguay-Spain game (8)
I believe the answer is:
roulette
'game' is the definition.
(roulette is a kind of game)
'one from latvia interrupting uruguay-spain' is the wordplay.
'one from latvia' becomes 'lett' (historical term for Latvian).
'interrupting' means one lot of letters goes inside another.
'uruguay' becomes 'rou' (abbreviation for Republica Oriental del Uruguay).
'spain' becomes 'e' (abbreviation for Espana).
'rou'+'e'='roue'
'lett' placed within 'roue' is 'ROULETTE'.
(Other definitions for roulette that I've seen before include "Half of 1D [GAME OR BIRD]" , "Table game" , "Spinning-wheel game" , "If Russian, it's a very dangerous game" , "Casino game" .)