One goes round with a despicable person (5)
I believe the answer is:
wheel
'one goes round' is the definition.
(a wheel turns round on an axis)
'with a despicable person' is the wordplay.
'with' becomes 'w' (abbreviation).
'a despicable person' becomes 'heel' (I've seen this before).
'w'+'heel'='WHEEL'
(Other definitions for wheel that I've seen before include "Turn in a wide circle" , "Revolutionary invention!" , "Move in a circle" , "Gyrate" , "revolutionary device" .)