One imprisoned as murderer (4)
I believe the answer is:
cain
'murderer' is the definition.
(Biblical figure)
'one imprisoned as' is the wordplay.
'one' becomes 'i' (Roman numeral).
'imprisoned' is an insertion indicator.
'as' becomes 'can' (I can't justify this - if you can you should give a lot more credence to this answer).
'i' inserted inside 'can' is 'CAIN'.
Can you help me to learn more?
(Other definitions for cain that I've seen before include "The first known murderer" , "Eldest son of Adam, Eve" , "Abel's brother" , "First murderer reported in the Bible" , "Brother of Abel" .)