One rambling old US leader appears in 60 Minutes (5)
I believe the answer is:
hiker
'one rambling' is the definition.
(a hiker rambles around)
'old us leader appears in 60 minutes' is the wordplay.
'old us leader' becomes 'Ike' (nickname of US President Dwight D Eisenhower).
'appears in' indicates putting letters inside.
'60 minutes' becomes 'hr' (synonyms).
'ike' placed within 'hr' is 'HIKER'.
(Other definitions for hiker that I've seen before include "I could be on the trail" , "Someone walking (with backpack?)" , "One putting up charges" , "One rambling" , "Person on long walk" .)