Opposed to a profit over the way (7)
I believe the answer is:
against
'opposed to' is the definition.
(thesaurus)
'a profit over the way' is the wordplay.
'profit over' becomes 'gain' ('gain' can be a synonym of 'profit'. I am not sure about the 'over' bit.**).
'the way' becomes 'st'.
'a'+'gain'+'st'='AGAINST'
Can you help me to learn more?
(Other definitions for against that I've seen before include "close by" , "In opposition to" , "on the other side" , "Disapproving of" , "Con" .)