Original in only one way? (3)
I believe the answer is:
new
'original' is the definition.
(similar in meaning)
'in only one way?' is the wordplay.
'in' indicates the answer is hidden within the clue.
'NEW' is hidden in the letters of 'only one way'.
(Other definitions for new that I've seen before include "'Fresh, novel (3)'" , "Fresh, recent" , "Recently made, etc" , "Unused or novel" , "Original" .)