Out East, a bit isolated (3,5)
I believe the answer is:
set apart
'isolated' is the definition.
(I've seen this before)
'out east a bit' is the wordplay.
'out' is an anagram indicator.
'a bit' becomes 'part' (both can mean a piece of something).
'east' is an anagram of 'seta'.
'seta'+'part'='SET APART'
(Other definitions for set apart that I've seen before include "specially allocated" , "Distinguished" , "Keep separate (for a special purpose)" , "Separated" , "Placed separately from others -as at repast?" .)