Permit, in the course of the game (8)
I believe the answer is:
roulette
'the game' is the definition.
(roulette is a kind of game)
'permit in the course' is the wordplay.
'permit' becomes 'let' ('let' can be a synonym of 'permit').
'in the' indicates putting letters inside.
'course' becomes 'route' (I've seen this before).
'let' going within 'route' is 'ROULETTE'.
'of' is the link.
(Other definitions for roulette that I've seen before include "Casino game" , "Wheel of fortune" , "it's a gamble" , "Gambling game with spinning wheel and ball" , "sort of gambling" .)