Picture game played by head of Interpol (5)
I believe the answer is:
image
'picture' is the definition.
('image' can be a synonym of 'picture')
'game played by head of interpol' is the wordplay.
'played' indicates an anagram.
'by' is a charade indicator (letters next to each other).
'head of' suggests taking the first letters.
The initial letter of 'interpol' is 'i'.
'game' anagrammed gives 'mage'.
'mage' put after 'i' is 'IMAGE'.
(Other definitions for image that I've seen before include "Visible representation" , "Likeness, could be spitting" , "Pictorial representation" , "Optical counterpart in mirror" , "Mental picture; metaphor" .)