Pioneering MP Nancy — minister powerless! (5)
I believe the answer is:
astor
'pioneering mp' is the definition.
(Nancy Astor, first female MP in UK)
I can't explain the remainder of the clue.
Can you help me to learn more?
(Other definitions for astor that I've seen before include "First female MP" , "female parliamentarian" , "Nancy --, one-time MP" , "Nancy ---, first woman MP" , "Female politician" .)