Pity has affected me (5)
I believe the answer is:
shame
'pity' is the definition.
(I know that pity can be written as shame)
'has affected me' is the wordplay.
'affected' indicates an anagram.
'has' is an anagram of 'sha'.
'sha'+'me'='SHAME'
(Other definitions for shame that I've seen before include "Disgrace, intense regret" , "disgraceful" , "scandal" , "Ignomony" , "Disgrace - Salman Rushdie novel" .)