Play first shot? (5)
I believe the answer is:
drama
'play first shot?' is the definition.
'drama' can be an answer for 'play' (I've seen this before). I am not sure about the 'first shot?' bit.
'play first shot?' is the wordplay.
'play' becomes 'a' (I can't justify this - if you can you should give a lot more credence to this answer).
'first' is a charade indicator (letters next to each other).
'shot?' becomes 'dram' (of whisky say).
'a' after 'dram' is 'DRAMA'.
(Other definitions for drama that I've seen before include "Turbulent emotional episode" , "Play (as a genre)" , "Highly emotional episode" , "Tragic situation" , "theatre production" .)