Point of no return after lodging new complaint (4)
I believe the answer is:
acne
'complaint' is the definition.
(acne is a kind of health problem)
'point of no return after lodging new' is the wordplay.
'point of no return' becomes 'ace' (tennis serve which is not returned).
'after lodging' indicates putting letters inside (inserted letters are lodged or hosted).
'new' becomes 'n' (common abbreviation eg NT for New Testament).
'ace' enclosing 'n' is 'ACNE'.
(Other definitions for acne that I've seen before include "Skin affliction" , "Adolescent spots" , "(Inflammation causing) spots" , "Face problems" , "Problem to face in" .)