Point up in pressure (6)
I believe the answer is:
stress
I believe this clue is a double definition.
'point up' is the first definition.
(I've seen this in another clue)
'pressure' is the second definition.
(I've seen this in another clue)
'in' is the link.
(Other definitions for stress that I've seen before include "Ictus" , "Force" , "suffering" , "why off work?" , "Tension - accent" .)