Port in W France at the head of the Loire estuary associated with a 1598 Edict (6)

I believe the answer is:

nantes

(Other definitions for nantes that I've seen before include "Loire city; its tolerant Edict" , "Port city in western France" , "French FC" , "French Atlantic port" , "City in Brittany" .)

I've seen this clue in The Independent.

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