President Satan concocted psychoactive drug (14)
I believe the answer is:
antidepressant
'psychoactive drug' is the definition.
(thesaurus)
'president satan concocted' is the wordplay.
'concocted' is an anagram indicator.
'president'+'satan'='presidentsatan'
'presidentsatan' anagrammed gives 'ANTIDEPRESSANT'.
(Other definitions for antidepressant that I've seen before include "Mood-lightening drug" , "Uplifting drug" .)