Principally adolescent curse, requiring prescription medicine ultimately? (4)

I believe the answer is:

acne

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'principally adolescent curse requiring prescription medicine ultimately?' is the definition.
I can't tell whether this definition defines the answer.

'principally adolescent curse requiring prescription medicine ultimately?' is the wordplay.
'principally' indicates taking the first letters.
'requiring' is a charade indicator (letters next to each other).
'ultimately?' suggests the final letters (I've seen 'ultimately' mean this).
The first letters of 'adolescent curse' is 'ac'.
The final letters of 'prescription medicine' are 'ne'.
'ac'+'ne'='ACNE'

Can you help me to learn more?

(Other definitions for acne that I've seen before include "Pimply skin condition of adolescence" , "Inflammation of glands in skin" , "Skin complaint" , "Skin condition prevalent among teenagers" , "Pimply ailment of adolescnce" .)

I've seen this clue in The Independent.

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