Profit from uranium found in valley (5)
I believe the answer is:
value
'profit' is the definition.
(thesaurus)
'uranium found in valley' is the wordplay.
'uranium' becomes 'U' (U is the chemical symbol for uranium).
'found in' is an insertion indicator.
'valley' becomes 'vale' (synonyms).
'u' put within 'vale' is 'VALUE'.
'from' acts as a link.
(Other definitions for value that I've seen before include "Cost" , "Assess, put a price on" , "Monetary worth" , "Estimate the worth of" , "Treasure" .)