Queen in flit with philanderer (5)
I believe the answer is:
flirt
'philanderer' is the definition.
(thesaurus)
'queen in flit' is the wordplay.
'queen' becomes 'r' (r is abbreviation regina. e.g. in ER ).
'in' means one lot of letters goes inside another.
'r' placed within 'flit' is 'FLIRT'.
'with' acts as a link.
(Other definitions for flirt that I've seen before include "Dalliance" , "Play at courtship" , "Behave playfully with opposite sex" , "Hussy" , "Philander(er)" .)