Rail links globe endlessly with American business (10)
I believe the answer is:
balustrade
'rail' is the definition.
(balustrade is a kind of rail)
'globe endlessly with american business' is the wordplay.
'globe' becomes 'ball' ('ball' can be a synonym of 'globe').
'endlessly' means to remove the last letter.
'with' is a charade indicator (letters next to each other).
'american' becomes 'us'.
'business' becomes 'trade' (trade is a kind of business**).
'ball' with its last letter taken away is 'bal'.
'bal'+'us'+'trade'='BALUSTRADE'
'links' acts as a link.
(Other definitions for balustrade that I've seen before include "Handrail" , "Railing on stairs or balcony" , "Form of railing" , "Row of pillars under rail" , "Railing at the side of a balcony" .)