Regularly observed twitch (3)
I believe the answer is:
tic
'regularly observed twitch' is the definition.
'tic' can be an answer for 'twitch' (tic is a kind of twitch). I'm not sure about the 'regularly observed' bit.
'regularly observed twitch' is the wordplay.
'regularly observed' means one should take alternating letters (letters selected at regular intervals).
The alternating letters of 'twitch' are 'TIC'.
Can you help me to learn more?
(Other definitions for tic that I've seen before include "Regular muscular twitch" , "Involuntary muscular spasm" , "Convulsive spasm" , "Convulsion" , "Facial muscle spasm" .)