Remove misguided male in tie (9)
I believe the answer is:
eliminate
'remove' is the definition.
(I know that eliminate is a more specific form of the action remove)
'misguided male in tie' is the wordplay.
'misguided' indicates anagramming the letters (letters guided into the wrong places).
'male'+'in'+'tie'='maleintie'
'maleintie' anagrammed gives 'ELIMINATE'.
(Other definitions for eliminate that I've seen before include "Wipe out" , "Completely remove, get rid of" , "Discard - exclude" , "Eradicate" , "Annihilate" .)