Roll with end of loaf (5)
I believe the answer is:
wheel
'roll' is the definition.
(synonyms)
'with end of loaf' is the wordplay.
'with' becomes 'w' (abbreviation).
'end of loaf' becomes 'heel' (the crusty end of a loaf of bread).
'w'+'heel'='WHEEL'
(Other definitions for wheel that I've seen before include "Turn in a wide 14 across" , "Roll" , "Circular structure on axle" , "Rotating circular frame" , "Turn round quickly" .)