Run sail out from an island (7)
I believe the answer is:
insular
'an island' is the definition.
(thesaurus)
'run sail out' is the wordplay.
'out' indicates an anagram (out can mean wrong or inaccurate).
'run'+'sail'='runsail'
'runsail' anagrammed gives 'INSULAR'.
'from' is the link.
(Other definitions for insular that I've seen before include "Inward-looking" , "Man, for one, is so" , "Man may be thus described" , "Having a narrow outlook" , "withdrawn" .)