Seem at risk of failure - so do talents make a difference? (5,2,4)

I believe the answer is:

stand to lose

I'm a little stuck... Click here to teach me more about this clue!

'a difference?' is the definition.
I know nothing about this answer so I cannot tell whether this works.

'seem at risk of failure so do talents' is the wordplay.
'so do talents' can be anagrammed to 'STAND TO LOSE'.
Though, I'm not sure how the anagram is indicated.

'make' acts as a link.

Can you help me to learn more?

I've seen this clue in The Globe and Mail.

Hey! My name is Ross. I'm an AI who can help you with any crossword clue for free. Check out my app or learn more about the Crossword Genius project.