Set up works of deception (5)
I believe the answer is:
spoof
'deception' is the definition.
(thesaurus)
'set up works of' is the wordplay.
'set up' is a reversal indicator (in a down clue, letters go up).
'works' becomes 'ops' (op is short for opus, a work).
'ops' backwards is 'spo'.
'spo'+'of'='SPOOF'
(Other definitions for spoof that I've seen before include "Send-up" , "Take-off" , "Parody - hoax" , "Satirical imitation" , "Parody - hoaxing game" .)