Setter barking in road (6)
I believe the answer is:
street
'road' is the definition.
(I know that road can be written as street)
'setter barking' is the wordplay.
'barking' is an anagram indicator ('barking' can informally mean mad).
'setter' with letters rearranged gives 'STREET'.
'in' is the link.
(Other definitions for street that I've seen before include "- Arab; - light" , "See 17" , "A thoroughfare or public road" , "Perry's Della" , "See 1 Down" .)