She brings endless anguish to a male (5)
I believe the answer is:
woman
'she' is the definition.
(I've seen this before)
'endless anguish to a male' is the wordplay.
'endless' means to remove the last letter.
'anguish' becomes 'woe' (I've seen this in another clue).
'to a male' becomes 'man' (man is a kind of male).
'woe' with its last letter taken off is 'wo'.
'wo'+'man'='WOMAN'
'brings' is the link.
(Other definitions for woman that I've seen before include "With 1a [OLD], one's rather timid" , "Lady" , "See 16" , "With 1a [NEW] a freedom fighter" , "Adult female" .)