She confuses the issue (5)
I believe the answer is:
Here is my best explanation:
'she' is the definition.
'confuses the issue' is the wordplay.
'confuses' is an anagram indicator.
'issue' with letters rearranged gives 'SUSIE'.
(Other definitions for susie that I've seen before include "Woman", "Girl", "Girl's name", "Tongue-twister sister sewing shirts for soldiers", "Little Susannah", "Wake Up Little - (Everly Brothers)" and "Old song: ''If you knew . . . . . like I know . . . . .''".)