She may take one in hand (5)
I believe the answer is:
dinah
'hand' is the definition.
Both the definition and answer are singular nouns.
Maybe you can see an association between them that I don't see?
'she may take one in' is the wordplay.
'she may' becomes 'dah' (I can't justify this - if you can you should give a lot more credence to this answer).
'take' means one lot of letters goes inside another.
'dah' going around 'in' is 'DINAH'.
Can you help me to learn more?
(Other definitions for dinah that I've seen before include "Washington perhaps" , "_____ 15+22, singer" .)