She'd clue 'pants' as something a secretary might have a hand in! (8)
I believe the answer is:
schedule
'something a secretary might have a hand in' is the definition.
(a secretary might be responsible for a schedule)
'she'd clue pants' is the wordplay.
'pants' indicates an anagram (UK informal term for 'nonsense' or 'rubbish').
'shed'+'clue'='shedclue'
'shedclue' anagrammed gives 'SCHEDULE'.
'as' acts as a link.
(Other definitions for schedule that I've seen before include "List of times when things should happen" , "Plan of activities" , "Table of events" , "Timetable of planned events or work" , "Rota" .)