Show great respect for son escaping misfortune (6)
I believe the answer is:
revere
'show great respect for' is the definition.
(to revere is to respect or honour)
'son escaping misfortune' is the wordplay.
'son' becomes 's' (genealogical abbreviation for son).
'escaping' suggests deleting specific letters.
'misfortune' becomes 'reverse' (a reversal of fortunes).
'reverse' with 's' taken out is 'REVERE'.
(Other definitions for revere that I've seen before include "Greatly respect" , "Hugely admire" , "Paul of the famous midnight ride" , "Renowned rider" , "Greatly admire" .)