Shut up about waste (5)
I believe the answer is:
close
'shut up' is the definition.
(thesaurus)
'about waste' is the wordplay.
'about' becomes 'c' (abbreviation for 'circa').
'waste' becomes 'lose'.
'c'+'lose'='CLOSE'
(Other definitions for close that I've seen before include "On intimate terms" , "small quiet road" , "cathedral precinct" , "Tightly" , "Not far off" .)