Sick, Gran Kelly upset about decay of tissue? (8)
I believe the answer is:
gangrene
'decay of tissue?' is the definition.
'gangrene' can be an answer for 'tissue?' (I have seen 'Necrotic tissue ' mean 'gangrene' so perhaps 'tissue' could also mean 'gangrene'). I'm not certain of the 'decay of' bit.
'sick gran kelly upset about' is the wordplay.
'sick' indicates anagramming the letters.
'kelly upset' becomes 'gene' (I am not sure about this - if you are sure you should believe this answer much more).
'about' indicates putting letters inside.
'gran' with letters rearranged gives 'angr'.
'angr' put within 'gene' is 'GANGRENE'.
Can you help me to learn more?
(Other definitions for gangrene that I've seen before include "Mortify" , "Decay of bodily tissue caused by blockage of blood supply" , "Death of part of the body" , "Decay of bodily tissue through bad circulation" , "Pathological condition" .)