Sign of very independent move to crush queen (5)
I believe the answer is:
virgo
'sign' is the definition.
(I know that Virgo is a sign)
'very independent move to crush queen' is the wordplay.
'very' becomes 'v' (abbreviation).
'independent' becomes 'i'.
'move' becomes 'go' (to go is to move).
'to crush' indicates putting letters inside (inserted letters are crushed between others).
'queen' becomes 'r' (abbreviation for regina, e.g. in ER ).
'i'+'go'='igo'
'igo' going around 'r' is 'irgo'.
'v'+'irgo'='VIRGO'
'of' acts as a link.
(Other definitions for virgo that I've seen before include "A constellation, a cluster" , "number of stars" , "House" , "Star sign" , "Large constellation -- sign of the zodiac" .)