Significance of devil's work? (6)
I believe the answer is:
impact
'significance' is the definition.
(I've seen this before)
'devil's work?' is the wordplay.
'devil' becomes 'imp' (I've seen this before).
'work?' becomes 'act' (work is a kind of act**).
'imp'+'act'='IMPACT'
'of' acts as a link.
(Other definitions for impact that I've seen before include "hit, in a big way" , "Serious effect" , "Forceful consequence" , "Marked effect or influence" , "Force of blow or collision" .)