Six-footer in quarantine (3)
I believe the answer is:
ant
'six-footer' is the definition.
(I've seen this before)
'in quarantine' is the wordplay.
'in' indicates the answer is hidden within the clue.
'ANT' is hidden in the letters of 'quarantine'.
(Other definitions for ant that I've seen before include "Small busy insect" , "Colonial insect?" , "A soldier, for one" , "that may be a soldier" , "Worker on the hill" .)