Skin complaint from cane, perhaps (4)
I believe the answer is:
acne
'skin complaint' is the definition.
(I've seen this before)
'cane perhaps' is the wordplay.
'perhaps' indicates an anagram.
'cane' anagrammed gives 'ACNE'.
'from' is the link.
(Other definitions for acne that I've seen before include "Adolescent spots" , "Problem to face in" , "Teenage skin blemish" , "Skin condition prevalent among teenagers" , "Skin disorder" .)