Sob as ET's drunk toxic stuff (8)
I believe the answer is:
asbestos
'toxic stuff' is the definition.
'asbestos' can be an answer for 'stuff' (asbestos is a kind of stuff). I am not sure about the 'toxic' bit.
'sob as et's drunk' is the wordplay.
'drunk' is an anagram indicator.
'sob'+'as'+'ets'='sobasets'
'sobasets' is an anagram of 'ASBESTOS'.
Can you help me to learn more?
(Other definitions for asbestos that I've seen before include "I might end up lagging" , "Fireproof material, now known to be dangerous" , "Once used for safety, it proved dangerous" , "risky material" , "dangerous dust" .)