Some microbes emulsify fat (5)
I believe the answer is:
obese
'fat' is the definition.
(similar in meaning)
'some microbes emulsify' is the wordplay.
'some' indicates a hidden word (some parts of the word are used).
'OBESE' is hidden in the letters of 'microbes emulsify'.
(Other definitions for obese that I've seen before include "likely to tip the balance?" , "Abnormally fat" , "Much too fat" , "Morbidly overweight" , "Morbidly fat" .)