Something to do with gum (4)
I believe the answer is:
chew
'gum' is the definition.
(I know that gum is a more specific form of chew)
'something to do with' is the wordplay.
'something to do' becomes 'che' (I can't explain this - if you can you should believe this answer much more).
'with' becomes 'w' (abbreviation).
'che'+'w'='CHEW'
Can you help me to learn more?
(Other definitions for chew that I've seen before include "Ruminate" , "Work or grind between teeth" , "Munch" , "champ" , "bit of tobacco" .)