Sometimes lie with canine who's barking (4,2,1,5)
I believe the answer is:
once in a while
'sometimes' is the definition.
(I know that sometimes can be written as once in a while)
'lie with canine who's barking' is the wordplay.
'with' is a charade indicator (letters next to each other).
'barking' indicates an anagram (UK slang for mad).
'lie'+'canine'+'who'='liecaninewho'
'liecaninewho' is an anagram of 'ONCE IN A WHILE'.
(Other definitions for once in a while that I've seen before include "Not very often" , "At times" , "Occasionally" , "Every now and again" .)