Sound coming from empty stomach (4)
I believe the answer is:
bear
'stomach' is the definition.
(both can mean to tolerate or endure)
'sound coming from empty' is the wordplay.
'sound coming from' shows a homophone (sound like).
'empty' becomes 'bare' (eg 'the cupboards were bare').
'bare' sounds like 'BEAR'.
(Other definitions for bear that I've seen before include "Tolerate; animal" , "Paddington, Rupert" , "eg Pooh" , "Press (on) - approach threateningly" , "It could be polar or grizzly" .)