South Carolina, uncommonly nice and picturesque (6)
I believe the answer is:
scenic
'picturesque' is the definition.
(thesaurus)
'south carolina uncommonly nice' is the wordplay.
'south carolina' becomes 'sc'.
'uncommonly' is an anagram indicator.
'nice' is an anagram of 'enic'.
'sc'+'enic'='SCENIC'
'and' is the link.
(Other definitions for scenic that I've seen before include "Like beautiful landscape" , "This route has pleasing vistas" , "Relating to beautiful view" , "Relating to picturesque countryside" , "Like lovely countryside" .)