Space in which to do wrong to us (5)
I believe the answer is:
sinus
'space' is the definition.
(I have seen 'Hollow space' mean 'sinus' so perhaps 'space' could also mean 'sinus')
'to do wrong to us' is the wordplay.
'to do wrong' becomes 'sin' (to sin is to do wrong or act badly).
'sin'+'us'='SINUS'
'in which' acts as a link.
(Other definitions for sinus that I've seen before include "Air-filled cavity of the skull" , "Head space" , "Hole in the head" , "Space in temple" , "Cavity in body (connecting to nose)" .)