Squint at hairless horse (8)
I believe the answer is:
skewbald
'horse' is the definition.
(I've seen this before)
'squint at hairless' is the wordplay.
'squint' becomes 'skew' ('squint' is a Scottish term for askew).
'at' means one lot of letters go next to another.
'hairless' becomes 'bald' ('bald' can be similar in meaning to 'hairless').
'skew'+'bald'='SKEWBALD'
(Other definitions for skewbald that I've seen before include "Marked with patches of white and a colour" , "Horse with patches of white and another colour" , "patchy" , "Bicoloured creature" , "maybe brown and white" .)