Struggle over wife's opinion (4)
I believe the answer is:
view
'opinion' is the definition.
('view' can be a synonym of 'opinion')
'struggle over wife's' is the wordplay.
'struggle' becomes 'vie' (I've seen this before).
'over' means one lot of letters go next to another.
'wife' becomes 'w'.
'vie'+'w'='VIEW'
(Other definitions for view that I've seen before include "appearance" , "belief" , "See" , "inspection" , "Outlook" .)