Subtlety is ignored in trial (6)
I believe the answer is:
nuance
'subtlety' is the definition.
(synonyms)
I cannot understand how the remainder of the clue works.
Can you help me to learn more?
(Other definitions for nuance that I've seen before include "Fine shade of meaning" , "Fine distinction" , "Slight difference in meaning etc" , "Subtle difference of meaning" , "Cue Ann into slight shade" .)