Suffering from a nip (4)
I believe the answer is:
pain
'suffering' is the definition.
(I've seen this before)
'from a nip' is the wordplay.
'from' indicates anagramming the letters (from the letters).
'a'+'nip'='anip'
'anip' is an anagram of 'PAIN'.
(Other definitions for pain that I've seen before include "Annoying person" , "can cause discomfort" , "Suffering, ache" , "Agony" , "Mental distress" .)